Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Apexbio Technology LLC 2X hyperfusion plus master mix 10X1ml
Our 2X Hyperfusion Plus Master Mix (With dye) product offers high fidelity strong amplification performance and faster extension speed simultaneously making it suitable for most PCR applications Hyperfusion Plus DNA Polymerase is created by fusing a Pyrococcus-like proofreading polymerase with a DNA binding domain providing increased fidelity and speed Hyperfusion Plus DNA Polymerase owns high fidelity 50 times lower error rate than Taq DNA Polymerase and 6 times lower error compared to Pyrococcus Furious DNA Polymerase Hyperfusion Plus DNA Polymerase exhibits both 5 to 3 polymerase activity and 3 to 5 exonuclease (proofreading) activity producing blunt-ended amplification products rather than A-tailed ends (commonly produced by Taq polymerase) Experimental results demonstrate that our Hyperfusion Plus polymerase can amplify genome fragments as long as 20 1 kb
Medchemexpress LLC ω-Agatoxin IVA TFA | 99.1% | 5316.27 | 1 MG
ω-Agatoxin IVA TFA is a potent and selective blocker of P/Q-type Ca2+ (Cav2.1) channels. It inhibits glutamate exocytosis and calcium influx induced by high potassium, and blocks the high potassium-induced release of serotonin and norepinephrine. This compound does not affect L-type or N-type calcium channels.
- Potent and selective blocker of P/Q-type Ca2+ (Cav2.1) channels
- Inhibits glutamate exocytosis and calcium influx induced by high potassium
- Blocks high potassium-induced release of serotonin and norepinephrine
- Does not affect L-type or N-type calcium channels
Medchemexpress LLC SAR441255 (TFA) | 99.9% | 4866.56 | 25 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys.
- Potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
- Displays high potency with balanced activation of all three target receptors.
- Shows positive acute glucoregulatory effects in diabetic obese monkeys.
Medchemexpress LLC D-phenylalanyl-prolyl-arginyl chloromethyl ketone trifluoroacetate | 157379-44-7 | 99.8% | 1 ML
PPACK TFA is a potent, selective, irreversible thrombin inhibitor supplied as a 10 mM solution in DMSO (1 mL). It is used as an anticoagulant and a biochemical tool to inhibit thrombin activity in blood-sample handling and enzymatic assays.
- Potent, selective, irreversible thrombin inhibitor.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High purity for reproducible experimental results.
- Molecular weight 564.99 g/mol; CAS 157379-44-7.
- Store sealed and away from moisture; follow storage instructions for solution and powder.
Medchemexpress LLC NN1177 (TFA) | 98.7% | 4570.07 (free base) | 25 MG
NN1177 TFA is a long-acting GLP-1/glucagon receptor co-agonist. It induces dose-dependent body weight loss in diet-induced obese mice. This product is for research use only.
- Long-acting GLP-1/glucagon receptor co-agonist
- Induces dose-dependent body weight loss in diet-induced obese mice
- Reduces CYP3A4 mRNA expression and activity in human hepatocytes
- Improves glucose tolerance in diet-induced obese mice
- Reduces liver fat and inflammatory biomarkers in NASH model mice
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | >91.6% | 4907.523 | 25 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist, suitable for various laboratory research applications. This synthetic peptide is often studied in antidiabetic research and related metabolic disease areas.
- Dual GIP/GLP-1 receptor agonist
- Ideal for antidiabetic research
- High purity for reliable results
- Synthetic peptide for consistent quality
- Suitable for various laboratory applications
Apexbio Technology LLC Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) 10x(1ml A 1ml B)
Under stable environmental conditions endogenous protein synthesis and degradation are balanced thus maintaining stable cellular protein levels Cell crude extracts contain numerous endogenous enzymes such as phosphatases and proteases that can degrade proteins in the extracts During in vitro protein extraction from cells and tissues protein synthesis practically ceases while protein degradation increases The optimal way to enhance yields of intact proteins is to add inhibitors for these known enzymes The Protease Inhibitor Cocktail for bacterial cell extracts (100X in DMSO) is designed for bacterial extracts to enhance the stability of proteins This cocktail inhibits proteases responsible for degrading non-phosphorylated or phosphorylated protein substrates This Protease Inhibitor Cocktail is provided as a ready-to-use solution and it is formulated in DMSO
Apexbio Technology LLC 5-hme-CTP 10x100ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Medchemexpress LLC Api137 TFA | 1428789-03-0 | 2291.71 | 1 MG
Api137 is an antimicrobial peptide designed to interfere with bacterial growth by inhibiting translation. It achieves this by trapping release factors on the 70S ribosome after the nascent polypeptide chain has been hydrolyzed, thereby preventing protein synthesis.
- Antimicrobial activity: effectively interferes with bacterial growth
- Translation inhibition: specific action on protein synthesis by targeting ribosomal release factors
- Research use only: intended for research purposes
- TFA form availability: available in a TFA (trifluoroacetate) form