Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC NNC9204-1177 (TFA) | 98.7% | 4570.07 (free base) | 1 MG
NN1177 TFA is a long-acting GLP-1/glucagon receptor co-agonist. It can induce a dose-dependent body weight loss in diet-induced obese (DIO) mice and reduces CYP3A4 mRNA expression and activity in human hepatocytes. It can also reduce liver fat and inflammatory and fibrosis biomarkers in a NASH mouse model.
- Induces dose-dependent body weight loss in diet-induced obese (DIO) mice.
- Reduces CYP3A4 mRNA expression and activity in human hepatocytes.
- Reduces liver fat and inflammatory and fibrosis biomarkers in a NASH mouse model.
Medchemexpress LLC Siivfekl (Tfa) | 99.9% | 948.16 | 5 MG
SIIVFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. It is an antigenic peptide used in experimental settings to stimulate specific T cells and study competitive interactions. This peptide exhibits low affinity for the OT-I T cell receptor (TCR) and is suitable for CD8+ T cell detection.
- Antigenic peptide.
- Stimulates specific T cells.
- Exhibits low affinity for OT-I T cell receptor (TCR).
- Used for detection of CD8+ T cells.
- Soluble in H2O at ≥ 2 mg/mL.
Medchemexpress LLC Lagipra peptide (TFA) | 98.2% | 5756.50 (free base) | 1 MG
LAGIPRA peptide TFA is a long-acting GIP1R agonist. It enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. This peptide has potential for the research of type 2 diabetes.
- Long-acting GIP1R agonist
- Enhances insulin sensitivity
- Reduces branched-chain amino acids (BCAAs)
- Reduces ketoacids
- Potential for type 2 diabetes research
Medchemexpress LLC Ant308 (TFA) | 99.6% | 3467.10 (free base) | 1 MG
ANT308 TFA is a vasoactive intestinal polypeptide (VIP receptor) antagonist that significantly enhances the activation and proliferation of T cells. It inhibits the migration and metastasis and induces apoptosis of melanoma tumor cells by inhibiting VIP-VPAC2 signaling. This compound reduces the expression of MCAM and N-cadherin, making it suitable for studies on acute myeloid leukemia (AML) and uveal melanoma (UVM).
- Vasoactive intestinal polypeptide (VIP receptor) antagonist
- Enhances T cell activation and proliferation
- Inhibits migration and metastasis of melanoma cells
- Induces apoptosis in melanoma tumor cells
- Inhibits VIP-VPAC2 signaling
- Reduces MCAM and N-cadherin expression
- Useful for acute myeloid leukemia (AML) research
- Useful for uveal melanoma (UVM) research
TARGETMOL CHEMICALS INC MM-102 TFA 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor with an IC50 of 2.4 nM. This compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5), inhibiting MLL1 H3K4 histone methyltransferase (HMT) activity and down-regulating H3K4me3, which facilitates the epigenetic reprogramming of porcine somatic cell nuclear transfer embryos. Purity 99.3%
Medchemexpress LLC L-Tyrosine, L-tyrosyl-L-lysyl-L-tyrosyl- (TFA) | 98.1% | 749.73 | 5 MG
YKYY TFA is a blood pressure-lowering peptide isolated from the digest of Undaria pinnatifida. This peptide acts as an angiotensin I-converting enzyme (ACE) inhibitor with an IC50 of 64.2 μM. It is suitable for use in hypertension research.
- Antihypertensive peptide
- Angiotensin I-converting enzyme (ACE) inhibitor
- Isolated from the peptic digest of wakame Undaria pinnatifida
- For research use only
Medchemexpress LLC NLS-StAx-h TFA | 98.9% | 3559.28 | 1 MG
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide that inhibits Wnt signaling, with an IC50 of 1.4 μM. It effectively inhibits interactions between β-catenin and transcription factors and demonstrates anti-proliferative effects on cancer cells, including SW-480 and DLD-1 colorectal cancer cells.
- Selective, cell permeable, stapled peptide
- Inhibits Wnt signaling with an IC50 of 1.4 μM
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation of cancer cells
- Inhibits proliferation of colorectal cancer cells (SW-480 and DLD-1 cells) by more than 80% at 10 μM
- Inhibits migration of DLD-1 colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC F9170 (TFA) | >98% | 2097.33 | 1 MG
F9170 (trifluoroacetate salt) is an antiviral peptide that corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein. This product is identified as a laboratory chemical for the manufacture of substances and is strictly for research use only. It must be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- Antiviral peptide.
- Corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein.
- Intended for research use only.
- Suitable for laboratory chemical applications.
- Recommended for handling by experienced personnel.
Medchemexpress LLC Charybdotoxin TFA | 96.8% | 4295.89 (free acid) | 100 UG
Charybdotoxin TFA is a 37-amino acid peptide that functions as a potassium channel blocker. This compound is a valuable tool for research involving potassium channels.
- Acts as a potassium channel blocker
- 37-amino acid peptide
- Useful for studying potassium channels
- Storage conditions for powder: -80°C for 2 years, -20°C for 1 year
- Storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month
- Sealed storage, away from moisture and light required for both forms
Medchemexpress LLC SIYNFEKL TFA | 99.9% | 1013.14 (free acid) | 5 MG
SIYNFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It stimulates specific T cells in experimental settings to study competitive interactions between T cells.
- Stimulates specific T cells
- Used to study competitive interaction between T cells
- Exhibits low affinity for OT-I T cell receptor (TCR)
- Applicable for detection of CD8+ T cells
Medchemexpress LLC Siivfekl (Tfa) | 99.85% | 948.16 | 1 MG
SIIVFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It is designed to stimulate specific T cells in experimental settings to study the competitive interaction between T cells. This peptide exhibits low affinity for the OT-I T cell receptor (TCR) and is suitable for the detection of CD8+ T cells.
- Variant of the major MHC class I-restricted epitope SIINFEKL
- Stimulates specific T cells for competitive interaction studies
- Exhibits low affinity for the OT-I T cell receptor (TCR)
- Suitable for detection of CD8+ T cells
- High purity of 99.85%
- Provided as a white to off-white solid
- Stable under recommended storage conditions
Medchemexpress LLC F9170 (TFA) | 99.7% | 1983.3 g/mol | 5 MG
F9170 (TFA) is a laboratory chemical with 99.7% purity and a molecular weight of 1983.3 g/mol. It appears as a solid and is stable under recommended storage conditions. This product is intended for research use only and should be handled by suitably qualified and experienced scientists in appropriate facilities.
- Solid appearance
- Stable under recommended storage conditions
- Store powder at -80°C for up to 2 years or -20°C for up to 1 year
- Store in solvent at -80°C for up to 6 months or -20°C for up to 1 month (sealed storage, away from moisture)
- Suitable for shipping at room temperature if less than 2 weeks
- Requires handling in areas with appropriate exhaust ventilation
- Keep container tightly sealed in a cool, well-ventilated area
- Keep away from direct sunlight and sources of ignition
Medchemexpress LLC Iberiotoxin (TFA) | 4230.85 | 500 UG
Iberiotoxin (TFA) is a selective high conductance Ca2+-activated K+ channel inhibitor with a Kd of approximately 1 nM. It does not block other types of voltage-dependent ion channels.
- Selective high conductance Ca2+-activated K+ channel inhibitor
- Kd of approximately 1 nM
- Does not block other types of voltage-dependent ion channels